Cucurbit[8]uril

CAS No. 259886-51-6

Cucurbit[8]uril ( —— )

Catalog No. M28058 CAS No. 259886-51-6

Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy trans

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 37 Get Quote
10MG 51 Get Quote
25MG 133 Get Quote
50MG 209 Get Quote
100MG 313 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Cucurbit[8]uril
  • Note
    Research use only, not for human use.
  • Brief Description
    Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy trans
  • Description
    Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy trans(In Vitro):Cucurbituril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%.Cucurbituril indeed selectively induces the heterodimerization of MV-eYFP with Np-eCFP. Cucurbituril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbituril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbituril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbituril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces.(In Vivo):Cucurbit[8]uril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Antibacterial;P. aeruginosa
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    259886-51-6
  • Formula Weight
    1329.1
  • Molecular Formula
    C48H48N32O16
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1N2CN3[C@H]4[C@H]5N(CN6[C@H]7[C@H]8N(CN9[C@H]%10[C@H]%11N(CN%12[C@H]%13[C@H]%14N(CN%15[C@H]%16[C@H]%17N(CN%18[C@H]%19[C@H]%20N(CN%21[C@H]%22[C@H]%23N(CN1[C@H]1[C@@H]2N2CN4C(=O)N5CN7C(=O)N8CN%10C(=O)N%11CN%13C(=O)N%14CN%16C(=O)N%17CN%19C(=O)N%20CN%22C(=O)N%23CN1C2=O)C%21=O)C%18=O)C%15=O)C%12=O)C9=O)C6=O)C3=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Fitzsimmons LF, et al. Small-molecule inhibition of choline catabolism in Pseudomonas aeruginosa and other aerobic choline-catabolizing bacteria. Appl Environ Microbiol. 2011 Jul;77(13):4383-9.
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