Cucurbit[8]uril
CAS No. 259886-51-6
Cucurbit[8]uril ( —— )
Catalog No. M28058 CAS No. 259886-51-6
Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy trans
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 37 | Get Quote |
|
10MG | 51 | Get Quote |
|
25MG | 133 | Get Quote |
|
50MG | 209 | Get Quote |
|
100MG | 313 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCucurbit[8]uril
-
NoteResearch use only, not for human use.
-
Brief DescriptionCucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy trans
-
DescriptionCucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy trans(In Vitro):Cucurbituril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%.Cucurbituril indeed selectively induces the heterodimerization of MV-eYFP with Np-eCFP. Cucurbituril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbituril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbituril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbituril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces.(In Vivo):Cucurbit[8]uril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorAntibacterial;P. aeruginosa
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number259886-51-6
-
Formula Weight1329.1
-
Molecular FormulaC48H48N32O16
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1N2CN3[C@H]4[C@H]5N(CN6[C@H]7[C@H]8N(CN9[C@H]%10[C@H]%11N(CN%12[C@H]%13[C@H]%14N(CN%15[C@H]%16[C@H]%17N(CN%18[C@H]%19[C@H]%20N(CN%21[C@H]%22[C@H]%23N(CN1[C@H]1[C@@H]2N2CN4C(=O)N5CN7C(=O)N8CN%10C(=O)N%11CN%13C(=O)N%14CN%16C(=O)N%17CN%19C(=O)N%20CN%22C(=O)N%23CN1C2=O)C%21=O)C%18=O)C%15=O)C%12=O)C9=O)C6=O)C3=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Fitzsimmons LF, et al. Small-molecule inhibition of choline catabolism in Pseudomonas aeruginosa and other aerobic choline-catabolizing bacteria. Appl Environ Microbiol. 2011 Jul;77(13):4383-9.
molnova catalog
related products
-
MSC2504877
MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phospho-Rb.
-
Bacopaside I
Bacopaside I is a saponin isolated from Bacopa monniera.?Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease.
-
L-838417 D9
L-838417 is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes.