Cucurbit[8]uril

Research use only, not for human use.

Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy trans

Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy trans(In Vitro):Cucurbituril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%.Cucurbituril indeed selectively induces the heterodimerization of MV-eYFP with Np-eCFP. Cucurbituril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbituril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbituril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbituril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces.(In Vivo):Cucurbit[8]uril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice.

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Others

Other Targets

Antibacterial;P. aeruginosa

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259886-51-6

1329.1

C48H48N32O16

>98% (HPLC)

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O=C1N2CN3[C@H]4[C@H]5N(CN6[C@H]7[C@H]8N(CN9[C@H]%10[C@H]%11N(CN%12[C@H]%13[C@H]%14N(CN%15[C@H]%16[C@H]%17N(CN%18[C@H]%19[C@H]%20N(CN%21[C@H]%22[C@H]%23N(CN1[C@H]1[C@@H]2N2CN4C(=O)N5CN7C(=O)N8CN%10C(=O)N%11CN%13C(=O)N%14CN%16C(=O)N%17CN%19C(=O)N%20CN%22C(=O)N%23CN1C2=O)C%21=O)C%18=O)C%15=O)C%12=O)C9=O)C6=O)C3=O

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(-20℃)

With Ice Pack

≥ 2 years